![]() It is the structure, which determines a protein’s biochemical functions, whereby structural similarity of one protein to another is an indication for similar function and/or evolutionary relation. The comparison of native three-dimensional (3D) protein structures is one of the most essential strategies of structural biology. Additionally, users can upload their own protein structures for pairwise protein structure comparison, alignment against all protein structures of the ASTRAL40 database (SCOP version 1.75) or symmetry analysis. GIS allows us to analyze protein structure families according to the SCOP classification scheme. We also allow to browse the ASTRAL40 database of protein structures with GANGSTA+ relative to an externally given protein structure using different constraints to select specific results. Here, we provide the resulting protein structure alignments as a public web-based service, named GANGSTA+ Internet Services (GIS). GANGSTA+ was applied in an all-against-all comparison on the ASTRAL40 database (SCOP version 1.75), which consists of >10 000 protein domains yielding about 55 � 10 6 possible protein structure alignments. α-helices and β-strands), it is able to detect structural similarities also between proteins whose sequences were reshuffled during evolution. Since GANGSTA+ ignores the polypeptide chain connectivity of secondary structure elements (i.e. GANGSTA+ can detect non-sequential structural analogs for proteins stated to possess novel folds. Recently, the non-sequential structure alignment algorithm GANGSTA+ was introduced. ![]() A web service for analysis of protein structures that are sequentially or non-sequentially similar was generated.
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